Pharmaceutics & Novel Drug Delivery Systems

Peptide and Protein Drug Delivery

Peptide and protein drugs have gained significant attention in the pharmaceutical industry due to their high specificity and efficacy in treating various diseases. However, their use is limited by challenges such as poor stability, low permeability, and rapid clearance from the body. To overcome these challenges, various drug delivery systems have been developed specifically for peptide and protein drugs. Nanotechnology-based drug delivery systems, such as nanoparticles, liposomes, and micelles, are used to encapsulate and deliver peptide and protein drugs. These systems protect the drugs from degradation, improve their stability, and enhance their bioavailability. Polymers, such as poly(lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG), are used to encapsulate peptide and protein drugs and control their release. These systems can provide sustained release of the drugs over an extended period. Transdermal delivery systems, such as patches and gels, are used to deliver peptide and protein drugs through the skin. These systems offer advantages such as non-invasiveness, sustained release, and avoidance of first-pass metabolism.