Pharmaceutics & Novel Drug Delivery Systems

Drug Delivery for Cardiovascular Diseases

Drug delivery for cardiovascular diseases aims to improve the efficacy and safety of therapeutics targeting heart conditions. Targeted drug delivery systems can deliver drugs directly to the site of action, such as the heart or blood vessels, minimizing systemic side effects. Nanoparticle-based drug delivery systems can improve the bioavailability and efficacy of cardiovascular drugs by enhancing their stability and targeting specific tissues. Stents coated with drugs can prevent restenosis (re-narrowing of blood vessels) by releasing drugs that inhibit cell proliferation at the site of stent placement. Long-acting or extended-release formulations can maintain therapeutic drug levels over an extended period, reducing the frequency of dosing. Gene delivery systems can be used to deliver therapeutic genes to target cells in the heart, offering potential for treating genetic cardiovascular disorders. Delivery of stem cells or progenitor cells to the heart can promote tissue repair and regeneration in conditions like myocardial infarction. Continuous infusion pumps can deliver drugs intravenously in controlled doses, especially in critical care settings. Formulations that improve the oral bioavailability of cardiovascular drugs can enhance patient compliance and convenience. Biodegradable polymers are used in drug delivery systems to deliver drugs over time and then degrade harmlessly in the body.