Biopharmaceutics and Drug Disposition
Biopharmaceutics and drug disposition are critical fields within pharmaceutical sciences that focus on the drug's journey from its formulation to its eventual action within the body and its elimination. These areas encompass the study of drug absorption, distribution, metabolism, and excretion (ADME), as well as the impact of formulation on drug performance. Biopharmaceutics examines how the physical and chemical properties of drugs, the formulation, and the route of administration influence the rate and extent of drug absorption into the bloodstream. The design and composition of the drug product, including the active pharmaceutical ingredient (API) and excipients. Formulation affects the drug's stability, solubility, and release rate. The path by which a drug is taken into the body, such as oral, intravenous, intramuscular, transdermal, or inhalational. Each route has distinct absorption characteristics and bioavailability. The process by which the drug dissolves in bodily fluids, impacting its absorption. Enhancing solubility can improve bioavailability, especially for poorly soluble drugs.
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