Day 1 :
- Pharmaceutical Formulations
Session Introduction
Badri Nagarani
Sri krupa Institute of Pharmaceutical Sciences, India.
Title: Formulation and evaluation of sustained release tablets of mangiferin: Natural compound
Biography:
B. Nagarani working as Assistant professor in Sri krupa Institute of Pharmaceutical Sciences in the department of Pharmaceutics, Velikatta. She has awarded the Bachelor’s degree from Sri krupa Institute of Pharmaceutical Sciences (Osmania University), Master’s degree from Sri krupa Institute of Pharmaceutical Sciences (Osmania University), Velikatta. She has more than 8 years’ experience in teaching and research. She is doing PhD in GITAM University; Vizag. She has published 20 articles in national and international journals. She presented poster and oral presentations in national and international conferences. She received gold medal for her Excellency in M Pharmacy. She has two patents in anti-diabetic area. She published four text books named Physical pharmacy-I and Industrial pharmacy-II. She published two book chapters. She is the lifetime member of APTI and registered with Telangana state Pharmacy council. She received international researcher award from International research Association, UK. She received young scientist award from INSO in 2022 at Chennai.
Abstract:
Analysis of extraction method using various solvents for efficient yield of biologically active compounds from natural source is very essential because there is large importance for the natural compounds in food, pharmacy and other allied industries. Mangiferin which is a xanthone compound present in high quantity in mango leaves and is endow to have anti diabetic activity along with other pharmacological activities. In present study an attempt was made to develop sustained release matrix tablets of Mangiferin using HPMC (K15M & K100M) and eudragit (RS 100 & RL 100) and Protanal as release retardant polymers. The Mangiferin matrix tablets were prepared by wet granulation method using lactose as a diluent. Formulations of different polymer percentages were formulated. The formulations were optimized on the basis of acceptable weight variation, thickness, hardness, % friability, % drug content and in vitro drug release. The in vitro release studies were performed using USP type II apparatus using 6.8 pH phosphate buffer as a dissolution medium, showed that optimized formulation F8 consisting of eudragit RL with 20% of the polymer was found to sustain the release of Mangiferin over a period of 12 h. The formulation exhibited highest correlation (R) value in case of Hixson-Crowell model and the release kinetic study proved that the formulation showed erosion process and shown to follow zero order kinetics. It was concluded that eudragit RL can be used for the preparation of sustained release tablet of ibuprofen.
- Drug Delivery Technologies
Session Introduction
Zulcaif
The University of Lahore, Pakistan
Title: Fabrication of fast dissolvable micro needle patch for transdermal delivery of simvastatin
Biography:
Zulcaif with a MPhil (1st Class) in Pharmacy from Riphah International University in 2019. Following a year of Pre-Registration training spent in Hospital Pharmacy, he joined School of Pharmacy at The University of Lahore to undertake a PhD in Pharmaceutics. He submitted PhD thesis in 2022 and appointed to a Lectureship in Pharmaceutics in September 2022 at The University of Lahore. Zulcaif research is centered on design and physicochemical characterization of advanced polymeric drug delivery systems for transdermal and topical drug delivery, with a strong emphasis on improving therapeutic outcomes for patients. His bio-adhesive patch design was used in successful photodynamic therapy of over 100 patients with neoplastic and dysplastic gynecological conditions and the patent subsequently out-licensed. Currently, Zulcaif research is focused on novel polymeric microneedle arrays for transdermal administration of "difficult-to-deliver" drugs.
Abstract:
Fast dissolving microneedles are one of the emerging approaches designed to enhance drug delivery involving minimal invasion. Herein, we report fast dissolvable microneedle (F-dMN) patches as a novel tool for better systemic delivery of Simvastatin in a patient friendly manner. Polyvinyl alcohol (PVA) and Polyvinylpyrrolidone (PVP) were used in the development of F-dMN patch. Developed formulations were characterized through SEM, FTIR, PXRD, dissolution testing, tensile strength, elongation (%), mechanical strength, skin irritation studies, and pharmacokinetic evaluation. Optimized F-dMN patch (G6) exhibited excellent elongation (35.17%), tensile strength (9.68MPa), moisture content (5.65%), penetration potential (~560µm) and Simvastatin release of 81.75%. Pharmacokinetic properties of fast dissolvable microneedle patches were also improved i.e., Cmax 6.974 µg/ml, tmax 1hr and AUC 19.518µg.h/ml as compared to tablet Simva solution thus confirming improved bioavailability. Kinetic modelling revealed hixson-crowell as best fit model for G6, based on regression coefficient. Histopathological findings proved good biocompatibility of the developed F-dMN patch. Moreover, stability studies (axial needle fracture force and drug content) of developed optimized microneedles patches confirmed the stability of the developed F-dMN patch.
- Drug Delivery Technologies
Session Introduction
Chaachouay Noureddine
FSK (Faculty of science in Kenitra) University, Morocco.
Title: Ethno medicinal studies on medicinal plants used by people of rif, morocco
Biography:
Chaachouay N has completed his/her PhD at the age of 30 years from FSK University, Morocco. He is the SVT professor of Al Majd high school, Morocco. He has over 4 publications that have been cited over 03 times, and his publication H-index is 4.
Abstract:
Medicinal and aromatic plants are a considerable source of active substances which are exploited in the treatment of several diseases. This study was carried out in the Rif (North of Morocco), it aimed to identify medicinal and aromatic plant used by the local people to treat digestive system diseases, together with the associated ethno medicinal knowledge. The ethno medical information collected was from 732 traditional healers using semi-structured interviews, free listing and focus group. Family use value (FUV), use value (UV), plant part value (PPV), fidelity level (FL) and Informant Agreement Ratio (IAR) were employed in data analysis. Medicinal and aromatic plant were collected, identified and kept at the natural resources and biodiversity laboratory, Ibn Tofail University, Kenitra. During the present study 87 medicinal plant species belonging to 43 families has been documented. The most frequent ailments reported were gastric ulcers (IAR = 0.97). The majority of the remedies were prepared from decoction (42.12%). Leaves were the most frequently used plant part (PPV = 0.344) and Thymus saturejoides Coss. (UV = 0.240) was the specie most commonly prescribed by local herbalists.
Conclusions: The results of this study showed that people living in the Rif of Morocco are still dependent on medicinal and aromatic plants. The documented plants can serve as a basis for further studies on the regions medicinal plants knowledge and for future phytochemical and pharmacological studies.