Zulcaif
The University of Lahore, Pakistan
Title: Fabrication of fast dissolvable micro needle patch for transdermal delivery of simvastatin
Biography
Biography: Zulcaif
Abstract
Fast dissolving microneedles are one of the emerging approaches designed to enhance drug delivery involving minimal invasion. Herein, we report fast dissolvable microneedle (F-dMN) patches as a novel tool for better systemic delivery of Simvastatin in a patient friendly manner. Polyvinyl alcohol (PVA) and Polyvinylpyrrolidone (PVP) were used in the development of F-dMN patch. Developed formulations were characterized through SEM, FTIR, PXRD, dissolution testing, tensile strength, elongation (%), mechanical strength, skin irritation studies, and pharmacokinetic evaluation. Optimized F-dMN patch (G6) exhibited excellent elongation (35.17%), tensile strength (9.68MPa), moisture content (5.65%), penetration potential (~560µm) and Simvastatin release of 81.75%. Pharmacokinetic properties of fast dissolvable microneedle patches were also improved i.e., Cmax 6.974 µg/ml, tmax 1hr and AUC 19.518µg.h/ml as compared to tablet Simva solution thus confirming improved bioavailability. Kinetic modelling revealed hixson-crowell as best fit model for G6, based on regression coefficient. Histopathological findings proved good biocompatibility of the developed F-dMN patch. Moreover, stability studies (axial needle fracture force and drug content) of developed optimized microneedles patches confirmed the stability of the developed F-dMN patch.